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2811849 
Journal Article 
Review 
Influence of insoluble excipients on film coating systems 
Felton, LA; Mcginity, JW 
2002 
Yes 
Drug Development and Industrial Pharmacy
ISSN: 0363-9045
EISSN: 1520-5762 
28 
3 
225-243 
English 
12026216 
WOS:000175491800001 
Insoluble excipients are added to polymeric film coating solutions and dispersions to improve the physical appearance of dosage forms, enhance the stability of photolytic drugs, and aid in processing. These insoluble additives, however, may significantly affect the physical, mechanical, adhesive, and drug-release properties of the films. In this review, the theories of the interactions between polymer and insoluble excipient are addressed. This article also discusses the influence of the concentration, particle size, morphology, and surface chemistry of insoluble excipients on the various polymer properties. 
adhesion; drug release; film coating; mechanical properties; pigments; talc