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2815809 
Journal Article 
Stability of isoniazid in aqueous solutions containing sucrose or sorbitol 
Hald, JG 
1969 
Yes 
Dansk Tidsskrift for Farmaci
ISSN: 0011-6513 
IPA/71/29100 
Tidsskr 
REF 2 
156-159 
English 
IPA COPYRIGHT: ASHP In the present paper it is shown that when stored, isoniazid in aqueous solutions of sucrose is probably decomposed by oxidation as well as by condensation. It is likely that the condensation is due to hydrolysis of sucrose to glucose and fructose, followed by formation of the corresponding isonicotinoyl hydrazones. The oxidation has been followed by bromometric titration. The untransformed isoniazid was condensed with benzaldehyde, extracted with chloroform as the benzaldehyde isonicotinoyl hydrazone and quantitatively determined by perchloric acid titration. Addition of sodium citrate reduces the rate of hydrolysis of the sucrose and consequently increases the stability. In aqueous solutions of sorbitol only oxidative decomposition affects the stability of isoniazid.