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2818717 
Journal Article 
Immediate and Delayed Sensitivity to Chlorocresol 
Goncalo, M; Goncalo, S; Moreno, A 
1987 
Yes 
Contact Dermatitis
ISSN: 0105-1873
EISSN: 1600-0536 
NIOSH/00174464 
17 
1 
46-47 
The case of a 35 year old female employed in a pathology laboratory who presented with simultaneous immediate and delayed hypersensitivity to p-chloro-m-cresol (59507) was reported. The patient developed acute dermatitis of the feet and face and was continuously treated with Diprosone cream, inducing a short lived improvement. The dermatitis was attributed to occupational exposure to disinfectant detergents. The dermatitis was unresponsive to several steroidal creams, including Emovate, Hidalone, and Betnovate, even when combined with systemic steroids. Four months following treatment, this patient experienced severe rhinitis, conjunctivitis, and lip and eyelid edema within one half hour of entering the pathology laboratory. These symptoms subsided upon termination of work in this laboratory, discontinuation of steroidal creams, and use of ointments for local treatment. Open tests and prick testing revealed a strong response to chlorocresol at 1 percent and 5 percent in a mixture of alcohol and water. Chlorocresol is used as a preservative in steroid creams as well as in disinfectants.