US EPA

2828319 

Book/Book Chapter 

Occupational and industrial dermatology 

1987 

Year Book Medical Publishers, Inc 

Chicago, Il 

Occupational and Industrial Dermatology 

1-477 

English 

has chapter(s) 2779060 Immediate contact reactions (contact urticaria syndrome)

The etiology and pathogenesis of the contact urticaria syndrome were reviewed. Contact symptoms to irritant agents included: local irritant reactions characterized by edema and erythema of the contact site; classical contact urticaria characterized by the wheal and flare; and other immediate reactions such as itching, tingling, and burning of the contact site without edema. The reactions were also differentiated on the basis of the ability of an irritant to produce irritant dermatitis with repeated applications. Diagnosis was complicated by the range of local symptoms and changes in reactions produced by different concentrations of the irritating agent and different sites of skin contact. The classification of contact urticaria according to pathophysiological mechanisms included: nonimmunologic contact urticaria; immunologic contact urticaria; and protein contact dermatitis. The most common causes of nonimmunologic contact urticaria were benzoic-acid, cinnamic-acid, cinnamic-aldehyde, and nicotinic-acid-esters. The primary cause of immunologic contact urticaria was foodstuffs. Protein contact dermatitis represented a subclassification of immunologic contact urticaria involving hand eczema with immediate exacerbation upon exposure to certain food proteins. The diagnosis of immediate contact reactions was described. 

Second Edition 

Maibach, HI 

9780815157298