Health & Environmental Research Online (HERO)


Print Feedback Export to File
2828995 
Journal Article 
Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids 
Kiuchi, F; Iwakami, S; Shibuya, M; Hanaoka, F; Sankawa, U 
1992 
Yes 
Chemical and Pharmaceutical Bulletin
ISSN: 0009-2363
EISSN: 1347-5223 
40 
2 
387-391 
English 
1606634 
The rhizomes of Zingiber officinale (ginger) and Alpinia officinarum contain potent inhibitors against prostaglandin biosynthesizing enzyme (PG synthetase). Gingerols and diarylhepatanoids were identified as active compounds. Their possible mechanism of action which was deduced from the structures of active compounds indicated that the inhibitors would also be active against arachidonate 5-lipoxygenase, an enzyme of leukotriene (LT) biosynthesis. This was verified by testing their inhibitory effects on 5-lipoxygenase prepared from RBL-1 cells. A diarylheptanoid with catechol group was the most active compound against 5-lipoxygenase, while yakuchinone A was the most active against PG synthetase.