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2837434 
Journal Article 
Arginine metabolism in asthma 
Scott, JA; Grasemann, H 
2014 
Yes 
Immunology and Allergy Clinics of North America
ISSN: 0889-8561
EISSN: 1557-8607 
34 
4 
767-775 
English 
25282289 
WOS:000343966200005 
Nitric oxide (NO) is important in the regulation of airway tone and airway responsiveness. Alterations in the L-arginine metabolism resulting in reduced availability of the substrate L-arginine for NO synthases, as well as the presence of NO synthase inhibitors such as asymmetric dimethylarginine, contribute to the reduced NO formation and airway dysfunction in asthma. Therapeutic interventions aiming to modulate the impaired L-arginine metabolism may help correct the enhanced airway tone and responsiveness in asthma. 
Arginine metabolism; Nitric oxide synthase; Arginase; Agmatine; Citrulline; Ornithine; Polyamine; ADMA