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HERO ID
2838123
Reference Type
Journal Article
Title
Rho-kinase as a therapeutic target in vascular diseases: striking nitric oxide signaling
Author(s)
Kolluru, GK; Majumder, S; Chatterjee, S
Year
2014
Is Peer Reviewed?
1
Journal
Nitric Oxide
ISSN:
1089-8603
EISSN:
1089-8611
Volume
43
Page Numbers
45-54
Language
English
PMID
25196952
DOI
10.1016/j.niox.2014.09.002
Web of Science Id
WOS:000346229900007
Abstract
Rho GTPases are a globular, monomeric group of small signaling G-protein molecules. Rho-associated protein kinase/Rho-kinase (ROCK) is a downstream effector protein of the Rho GTPase. Rho-kinases are the potential therapeutic targets in the treatment of cardiovascular diseases. Here, we have primarily discussed the intriguing roles of ROCK in cardiovascular health in relation to nitric oxide signaling. Further, we highlighted the biphasic effects of Y-27632, a ROCK inhibitor under shear stress, which acts as an agonist of nitric oxide production in endothelial cells. The biphasic effects of this inhibitor raised the question of safety of the drug usage in treating cardiovascular diseases.
Keywords
Rho-GTPases; Nitric oxide; Shear stress; ROCK inhibitors
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