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2839061 
Journal Article 
An Efficient and Convenient Synthesis of 4,6-Dichloro-2-methyl-5-nitropyrimidine 
Zhou, S; Xu, D; Wang, Z; Zhu, Z; Zha, Z; Fan, Yu; Su, H 
2014 
Yes 
Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X 
26 
12 
3559-3561 
WOS:000343762400027 
A convenient synthesis of 4, 6-dihydro-2-methyl-pyrimidine can be obtained by cyclization reaction of acetamidine hydrochloride and diethyl malonate in the presence of sodium methoxide for a 91.2 % yield. 4, 6-Dihydro-2-methyl-5-nitropyrimidine can be achieved by nitration under the mixed acids of nitric acid, trichloroacetic acid and acetic acid in an 88.3 % yield and then the chlorination using phosphorus oxytrichloride can afford 4, 6-dichloro-2-methyl-5-nitropyrimidine with an 82.6 % yield. 
Pyrimidine; Cyclization; Nitration; Chlorination; Synthesis