Health & Environmental Research Online (HERO)


Print Feedback Export to File
2841360 
Journal Article 
Effect of Active Hexose Correlated Compound (AHCC) in Alcohol-Induced Liver Enzyme Elevation 
Kim, H; Kim, JHa; Im, JeeAee 
2014 
Yes 
Journal of Nutritional Science and Vitaminology
ISSN: 0301-4800 
60 
5 
348-356 
25744424 
WOS:000344202700007 
To investigate the effects of Active Hexose Correlated Compound (AHCC) supplementation and the mechanism action of AHCC in patients with alcohol-induced mildly elevated liver enzyme levels, participants were randomly allocated to the placebo, 1 g AHCC, or 3 g AHCC group and took the supplement for 12 wk. Subjects visited the hospital for clinical and biochemical measurements, for examination of adverse events, to return unused supplements, and to obtain their next supplements. Biochemical tests including liver enzymes, a questionnaire survey, and anthropometric measurements were collected at baseline and every 4 wk thereafter. Adherence and adverse events were evaluated. After 12 wk of supplementation, the percentage change in alanine aminotransferase (ALT) level was significantly different between the placebo (4.02 +/- 59.07%) and both AHCC groups (1 g AHCC: -23.89 +/- 20.59%, 3 g AHCC: -24.09 +/- 30.73%) (p=0.04). Serum levels of tumor necrosis factor-alpha (p<0.05) and interleukin-1 beta (p<0.01) were significantly lower, while those of adiponectin were higher in both AHCC groups than in the placebo group (p<0.01). AHCC supplementation for 12 wk may improve the levels of liver enzymes and circulating pro-inflammatory and anti-inflammatory cytokines in patients with alcohol-induced liver enzyme elevation with mildly elevated liver enzyme levels. 
alcoholic liver disease; alanine aminotransferase; active hexose correlated compound; adiponectin