Synthesis and discovery of (I-3,II-3)-biacacetin as a novel non-zinc binding inhibitor of MMP-2 and MMP-9 | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2850249

Reference Type

Journal Article

Title

Synthesis and discovery of (I-3,II-3)-biacacetin as a novel non-zinc binding inhibitor of MMP-2 and MMP-9

Author(s)

Nanjan, P; Nambiar, J; Nair, BG; Banerji, A

Year

2015

Is Peer Reviewed?

Yes

Journal

Bioorganic & Medicinal Chemistry
ISSN: 0968-0896
EISSN: 1464-3391

Volume

Issue

Page Numbers

3781-3787

Language

English

PMID

25907368

DOI

10.1016/j.bmc.2015.03.084

Web of Science Id

WOS:000355848900084

Abstract

Eleven biflavones (7a-b and 9a-i) were synthesised by a simple and efficient protocol and screened for MMP-2 and MMP-9 inhibitory activities. Amongst them, a natural product-like analog, (I-3,II-3)-biacacetin (9h) was found to be the most potent inhibitor. Molecular docking studies suggest that unlike most of the known inhibitors, 9h inhibits MMP-2 and MMP-9 through non-zinc binding interactions.