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HERO ID
2856451
Reference Type
Journal Article
Subtype
Review
Title
Environmental studies of schizophrenia through the prism of epigenetics
Author(s)
Oh, G; Petronis, A
Year
2008
Is Peer Reviewed?
1
Journal
Schizophrenia Bulletin
ISSN:
0586-7614
EISSN:
1745-1701
Volume
34
Issue
6
Page Numbers
1122-1129
Language
English
PMID
18703665
DOI
10.1093/schbul/sbn105
Abstract
Traditionally, etiological research of schizophrenia has been focused on elucidating predisposing genes and environmental risk factors. While numerous putative environmental hazards have been suggested, inconsistencies and methodological limitations of epidemiological studies have made it difficult to identify even a single exogenous cause of schizophrenia. Furthermore, there is increasing evidence that environmental risk factors may not play as much of a significant role in schizophrenia as previously suspected. In this article, we argue that molecular epigenetic studies can overcome the complexities of traditional epidemiological studies and may become a productive line of research in understanding the nongenetic mechanisms of schizophrenia.
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