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2861890 
Journal Article 
Review 
Staphylococcus epidermidis - the 'accidental' pathogen 
Otto, M 
2009 
1 
Nature Reviews. Microbiology
ISSN: 1740-1526
EISSN: 1740-1534 
7 
8 
555-567 
English 
19609257 
WOS:000268069100009 
Although nosocomial infections by Staphylococcus epidermidis have gained much attention, this skin-colonizing bacterium has apparently evolved not to cause disease, but to maintain the commonly benign relationship with its host. Accordingly, S. epidermidis does not produce aggressive virulence determinants. Rather, factors that normally sustain the commensal lifestyle of S. epidermidis seem to give rise to additional benefits during infection. Furthermore, we are beginning to comprehend the roles of S. epidermidis in balancing the epithelial microflora and serving as a reservoir of resistance genes. In this Review, I discuss the molecular basis of the commensal and infectious lifestyles of S. epidermidis.