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2874863 
Journal Article 
A highly para-selective copper(II)-catalyzed direct arylation of aniline and phenol derivatives 
Ciana, CL; Phipps, RJ; Brandt, JR; Meyer, FM; Gaunt, MJ 
2011 
Yes 
Angewandte Chemie (International Edition)
ISSN: 1433-7851
EISSN: 1521-3773 
50 
2 
458-462 
English 
21140387 
WOS:000286729300020 
In short order: A copper-catalyzed Friedel-Crafts-type strategy has been developed for the title reaction. An iterative C-H arylation strategy has also been demonstrated for the functionalization of anilines by sequentially delivering different aromatic groups to the para, ortho, and meta positions (see scheme, Bn=benzyl, Piv=pivaloyl). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 
aromatic substitution; C-H arylation; copper; hypervalent iodine; synthetic methods