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2895299 
Technical Report 
Immunotoxicology of Exposure to JP-8 Jet Fuel 
Harris, D 
1997 
NTIS/03001313 
GRA and I 
GRA and I 
Chronic jet fuel exposure could be detrimental to Air Force personnel, by not only adversely affecting their work performance but also by predisposing these individuals to increased incidences of infectious disease, cancer and autoimmune dysfunctions. Chronic exposure to jet fuel has been shown to adversely affect human liver function, to cause emotional dysfunction, to cause abnormal electroencephalograms, to cause shortened attention spans, and to decrease sensorimotor speed. Currently, there are no standards for personnel exposure to jet fuels of any kind, let along JP-8 jet fuel. Kerosene based petroleum distillates have been associated with hepatic, renal, neurologic and pulmonary toxicity in animals models and human occupational exposures. The U.S. Department of Labor, Bureau of Labor statistics estimates that over 1.3 million workers were exposed to jet fuels in 1992. Thus, jet fuel exposure may not only have serious consequences for USAF personnel, but also may have potential harmful effects upon a significant number of civilian workers. Short-term (7 day) JP-8 jet fuel exposure causes lung injury as evidenced by increased pulmonary resistance, a decrease in bronchoalveolar lavage concentrations of substance P, increased wet lung/body weight ratio, and increased alveolar permeability. Long-term exposures, although demonstrating evidence of lung recovery, results in injury to secondary organis such as liver, kidneys and spleen.