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HERO ID
2897466
Reference Type
Journal Article
Title
The sub-chronic toxicity of regular White Spirit in rats
Author(s)
Carrillo, J-C; Adenuga, MD; Mckee, RH
Year
2014
Is Peer Reviewed?
1
Journal
Regulatory Toxicology and Pharmacology
ISSN:
0273-2300
EISSN:
1096-0295
Volume
70
Issue
1
Page Numbers
222-230
Language
English
PMID
25013991
DOI
10.1016/j.yrtph.2014.07.007
Web of Science Id
WOS:000342482200024
Abstract
Hydrocarbon solvents are mostly complex substances (UVCB) with carbon numbers in the range of approximately C5-C20. One of the most common types is a C9-C14 aliphatic solvent containing approximately 20% aromatics and commonly known as White Spirit in Europe and mineral spirits in the US. In previous repeated inhalation toxicity studies, White Spirit was reported to cause minimal systemic effects in most animal species with few effects other than male rat-specific kidney changes at levels up to approximately 2000mg/m(3). In the present study male and female rats were exposed to White Spirit vapors, 6h/day, 5days/week for 13weeks at levels of approximately 2000, 4000, or 8000mg/m(3) to assess the potential for effects at higher exposure levels. All of the rats survived the treatment period. In life observations were largely restricted to acute central nervous system (CNS) effects in the high exposure group. Terminal body weights of high exposure groups animals were significantly below control values. Statistically significant differences in the clinical and hematological observations were small and within normal physiological limits. Weights of some organs including liver, spleen and kidneys were elevated, but microscopic examination indicated that the only pathological effects were changes in the kidneys of the male rats, consistent with an α2u-globulin-mediated process, which is gender and species-specific and not relevant to humans. The overall no observed adverse effect level (NOAEC) was 4000mg/m(3).
Keywords
Alkanes; Aromatic hydrocarbons; Sub-chronic toxicity; Inhalation toxicity; Occupational exposure limit; Liver enlargement; UVCB; Hydrocarbon solvent; Stoddard solvent; White spirit
Tags
IRIS
•
Trimethylbenzenes (Interagency Science Discussion Draft)
Literature Search Update
Literature Search Update- Considered
Cited
Cited August 2016
Cited Toxicological Review
Cited Supplemental Information
•
Trimethylbenzenes (TMB)
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