Health & Environmental Research Online (HERO)


Print Feedback Export to File
29037 
Journal Article 
Enzymatic dehalogenation of certain brominated and chlorinated compounds 
Heppel, LA; Porterfield, VT 
1948 
Yes 
Journal of Biological Chemistry
ISSN: 0021-9258
EISSN: 1083-351X 
176 
763-769 
The enzymatic dehalogenation of CH2BrCl, CH2Br2, CH2Cl2, CH2Br.CH2Br, CH2Cl.CH2Cl, ChCl3, C2H5Br, and CH2Cl.CH2Br has been demonstrated in liver extracts. The products of reaction with CH2BrCl, CH2Br2, and CH2Cl2 were formaldehyde, halide ion, and hydrogen ion. The enzyme system required activation by cyanide and either glutathione or cysteine. A 5-fold purification was achieved by fractionation of liver extracts with ammonium sulfate.