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2915952 
Journal Article 
Identification of a reduced form of chlordecone (Kepone) in human stool 
Blanke, RV; Fariss, MW; Guzelian, PS; Paterson, AR; Smith, DE 
1978 
Yes 
Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 
NIOSH/00168289 
20 
6 
782-785 
English 
86368 
The biotransformation of chlordecone (143500) (Kepone) to metabolites extractable from human stool specimens was investigated in patients with a diagnosis of chlordecone toxicity. Extraction techniques included solvolysis followed by clean up and subsequent gas/liquid chromatography utilizing an electron capture detector. Use of authenticated standards suggested that the metabolite was decachlorooctahydro-1,3,4-metheno-2H-cyclobuta-(c,d)-pentalen-2-ol, resulting from attack on the hydrated carbonyl group and reduction to the corresponding alcohol. The common name chlordecol was proposed for this compound. It was not known whether this metabolite was formed in the liver and excreted into the bile or whether reduction occurred via the action of bacterial flora.