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2915988 
Journal Article 
Antibody reactivation of kepone inhibited brain ATPase activities 
Koch, RB; Desaiah, D; Glick, B; Subba Rao, DS; Stinson, R 
1977 
Yes 
General Pharmacology
ISSN: 0306-3623
EISSN: 1879-0011 
PESTAB/78/0168 
8 
4 
231-234 
English 
73494 
PESTAB. The antibody reactivation of kepone (chlordecone) inhibited brain ATPase activities was studied. Kelevan (a Kepone derivative) was covalently bound to bovine serum albumin (BSA) through a succinimide derivative, and rabbits were immunized by injection of the hapten-protein conjugate in an emulsion of Freund's complete adjuvant. Immunoglobulin fractions were prepared from control and immune rabbit serum, and immunoglobulin from BSA-Kel antiserum produced a complete reversal of Kepone inhibition of dog brain ATPase activities under the given experimental conditions. The results of this study indicate that in studies with the chlorinated hydrocarbon pesticides such as kepone and DCPD, one must be careful during tissue preparation to minimize possible reversal of ATPase inhibition.