US EPA

2916051 

Journal Article 

The in vivo effects of dietary mirex on hepatic lactic dehydrogenase and glutamic oxaloacetic transaminase levels of the rat 

Abston, PA; Yarbrough, JD 

1974 

Yes 

Journal of Agricultural and Food Chemistry
ISSN: 0021-8561
EISSN: 1520-5118 

PESTAB/74/0901 

22 

1 

66-68 

English 

4811637 

PESTAB Adult male and female Sprague�Dawley rats were fed standard laboratory chow, ad libitum containing mirex in concentrations of 10, 50, 100, and 200 ppm for 4 weeks. Liver homogenates were analyzed for lactic dehydrogenase and glutamic-oxaloacetic transaminase activity. Male liver LDH levels were reduced approxmiately 50% in the 100 and 200 ppm of mirex exposed animals, as compared to control animals, by 2 weeks of dietary mirex and persisted through the test period. Liver GOT levels showed a steady decrease in activity, exhibiting a 60-65% decrease at the end of the 4-week treatment period. With 10 ppm of dietary mirex, male liver LDH levels showed no significant change during the 4-week period, while liver GOT levels were reduced about 26% at the end of 3 weeks. Female rat liver homogenates exhibited an approximate 24% decrease in LDH levels after 3 weeks of dietary feeding of 100 ppm of mirex, while liver GOT levels were reduced about 35% when compared to control animals at 3 weeks. Female rats fed 50 ppm of mirex showed an approximate 25% reduction of LDH levels and about a 28% decrease in GPT liver levels after 4 weeks of exposure. (Author abstract reprinted by permission of the American Chemical Society)