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2917785 
Journal Article 
A study of tobacco carcinogenesis: I. The primary fractions 
Wynder, EL; Wright, G 
1957 
Yes 
Cancer
ISSN: 0008-543X
EISSN: 1097-0142 
10 
2 
255-271 
English 
Clinical, statistical, and pathological studies linking cancer of the lung, oral cavity, and larynx with tobacco smoking have led to an intensive study of tobacco, in particular of cigarettes, as a possible carcinogenic agent for laboratory animals. Several recent investigations have demonstrated condensed cigarette tar to be carcinogenic to the skin of several strains of mice, as well as to that of rabbits. In view of these results, it became of interest to determine the nature of the carcinogen or carcinogens responsible for these observations. For this reason, a combined chemical and biological study program was undertaken in 1952. The initial results are presented in this publication. Preliminary data have been published in part elsewhere.

For this study, vie carried out chemical fractionation, molecular distillation, and ion exchange experiments with tobacco-smoke condensate, referred to as "tar" throughout this report. In addition we compared the effect of the neutral fraction from smoked cigarettes with the effect of the neutral fraction from cigarette tobacco smoked in briar pipes. We also compared the activity of cigarette-smoke condensate with that of cigarette extract.