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2917831 
Technical Report 
Effect of Kepone (chlordecone) on synaptosomal catecholamine uptake in the mouse 
Chang-Tsui, YYH; Ho, IK 
1980 
PESTAB/80/1712 
3 
3 
PESTAB. Mouse brain crude synaptosomal fractions were exposed to Kepone (chlordecone) at final concentrations of 1, 5, 10, 50, 100 and 500 muM. In a further study, groups of mice were given Kepone po at 50 mg/kg for 2 or 3 days. In the in vitro studies Kepone demonstrated a dose-dependent inhibition of catecholamine uptake into synaptosomes. The uptake of dopamine or norepinephrine decreased dramatically as the concentration of Kepone increased from 5 to 50 muM. Similar reductions of the synaptosomal uptakes of both dopamine and norepinephrine were noted in the in vivo studies conducted over a 3 day period. In mice treated for 2 days, the dopamine uptake was not significantly lower than controls and the norepinephrine uptake was not changed from control levels. These results substantiate the theory that Kepone-induced neurotoxicity may be due partly to its effect on the neurotransmitter uptake process.