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HERO ID
2917887
Reference Type
Technical Report
Title
Effect of phenobarbitone pretreatment on the metabolism of neostigmine in vivo and in vitro
Author(s)
Ashford, JJ; Husain, MA; Roberts, JB; Thomas, BH; Wilson, A
Year
1970
Report Number
IPA/70/07694
Volume
Pharmacol
Issue
REF 11
Page Numbers
2069-2073
Language
English
Abstract
IPA COPYRIGHT: ASHP Increased excretion of the glucuronide of 3-hydroxyphenyltrimethyl ammonium in urine occurred in rats pretreated with phenobarbitone (phenobarbital) after a single intramuscular injection of 14C-neostigmine. No increase in the metabolism of neostigmine to 3-hydroxyphenyltrimethyl ammonium was observed in vitro with microsome preparations from the livers of rats pretreated with phenobarbitone. A significant increase in urinary excretion of the glucuronide of 3-hydroxyphenyltrimethyl ammonium occurred in phenobarbitone pretreated rats after a single injection of 3-hydroxyphenyltrimethyl ammonium.
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