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2917887 
Technical Report 
Effect of phenobarbitone pretreatment on the metabolism of neostigmine in vivo and in vitro 
Ashford, JJ; Husain, MA; Roberts, JB; Thomas, BH; Wilson, A 
1970 
IPA/70/07694 
Pharmacol 
REF 11 
2069-2073 
English 
IPA COPYRIGHT: ASHP Increased excretion of the glucuronide of 3-hydroxyphenyltrimethyl ammonium in urine occurred in rats pretreated with phenobarbitone (phenobarbital) after a single intramuscular injection of 14C-neostigmine. No increase in the metabolism of neostigmine to 3-hydroxyphenyltrimethyl ammonium was observed in vitro with microsome preparations from the livers of rats pretreated with phenobarbitone. A significant increase in urinary excretion of the glucuronide of 3-hydroxyphenyltrimethyl ammonium occurred in phenobarbitone pretreated rats after a single injection of 3-hydroxyphenyltrimethyl ammonium.