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2917912 
Journal Article 
Phenobarbital stability in different dosage forms: alternatives for elixirs 
Dietz, NJ; Cascella, PJ; Houglum, JE; Chappell, GS; Sieve, RM 
1988 
1 
Pharmaceutical Research
ISSN: 0724-8741
EISSN: 1573-904X 
IPA/89/866252 
Res 
REF 5 
803-805 
English 
IPA COPYRIGHT: ASHP The stability of phenobarbital sodium (I) as an elixir, emulsion, aqueous solution, and aqueous solution with propylene glycol is reported. The results show that I was stable in an elixir, an emulsion, and propylene glycol aqueous solution. The stability of the propylene glycol emulsion was attributed both to the solubilization of I in the oil phase and to the use of propylene glycol in the aqueous phase. This study supports the hypothesis that it may be possible to maintain stability of drugs prone to degradation in aqueous solutions by dispersing them in an emulsion as an alternative to an elixir.