Characterization of p-hydroxyphenobarbital glucuronide generated from immobilized rat hepatic UDP-glucuronosyltransferase | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2918413

Reference Type

Journal Article

Subtype

Letter

Title

Characterization of p-hydroxyphenobarbital glucuronide generated from immobilized rat hepatic UDP-glucuronosyltransferase

Author(s)

Studenberg, SD; Price-Raybuck, DL; Unger, SE; Shockcor, J; Brouwer, KL

Year

1995

Is Peer Reviewed?

Yes

Journal

Journal of Pharmaceutical Sciences
ISSN: 0022-3549
EISSN: 1520-6017

Publisher

AMER PHARMACEUTICAL ASSN

Location

WASHINGTON

Report Number

IPA/96/1099487

Volume

Pharm

Issue

REF 18

Page Numbers

1995

Language

English

PMID

8537894

DOI

10.1002/jps.2600840918

Web of Science Id

WOS:A1995RU65900017

Abstract

IPA COPYRIGHT: ASHP A modified method for the in vitro generation of glucuronides was developed using immobilized rat hepatic uridine-5'-diphosphoglucuronosyltransferase instead of rabbit uridine-5'-diphosphoglucuronosyltransferase, and the applicability of this modification was demonstrated by the generation of p-hydroxyphenobarbital glucuronide, a metabolite of phenobarbital.