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HERO ID
2918647
Reference Type
Technical Report
Title
Species differences in the hepatic response to insecticides
Author(s)
Abraham, R; Fulfa, J; Mayes, B; Coulston, F
Year
1977
Report Number
PESTAB/80/1384
Volume
Pollut
Page Numbers
pp
Abstract
PESTAB. The livers of monkeys, rats and mice were examined over a period of 3 yr to determine species response differences to mirex. Mirex was administered by stomach tube to rhesus monkeys at 5 and 20 ppm for 6 days/wk for up to 3 yr. Mice were given mirex at levels of 1 and 5 ppm and rats received 5 ppm. Acid phosphatase (AcPase) and glucose-6-phosphatase (G-6-Pase) activities were not changed in livers of mice receiving 1 ppm. G-6-Pase activity decreased in the centrilobular areas of mouse livers while AcPase activity increased with time in the 5 ppm group. Rat livers had no increased in AcPase activity and only a marginal loss in G-6-Pase activity. Monkey livers demonstrated no loss of G-6-Pase or activation of AcPase. The underlying feature in all livers was proliferation of smooth endoplasmic reticulum.
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