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2918875 
Journal Article 
Hepatoprotective activity of verbenalin on experimental liver damage in rodents 
Singh, B; Saxena, A; Chandan, BK; Anand, KK; Suri, OP; Suri, KA; Satti, NK 
1998 
Yes 
Fitoterapia
ISSN: 0367-326X 
69 
2 
135-140 
WOS:000074294800006 
The effects of an oral administration of verbenalin were studied for its hepatoprotective activity. Hexobarbitone-induced sleeping time, zoxazolamine-induced paralysis time, bromosulphalein (BSP) retention, serum levels of transaminases, bilirubin and total protein were used as indices of liver injury. A significant hepatoprotective effect was observed as evident from shortened hexobarbitone sleeping time and zoxazolamine paralysis time in mice which were increased by CCl4 treatment. Further, pre- and post-treatment with verbenalin reduced plasma BSP in mice, serum transaminases and bilirubin in rats in a dose-dependent manner as compared to CCl4 - treated animals. Verbenalin did not show any sign of toxicity and the minimum lethal dose was greater than 3.0 g/kg when given orally or intraperitoneally in mice. 
Verbena officinalis; iridoid glycosides; verbenalin; hepatoprotective activity