Health & Environmental Research Online (HERO)


Print Feedback Export to File
2950243 
Journal Article 
Review 
Manganese deficiency and toxicity: Are high or low dietary amounts of manganese cause for concern? 
Finley, J; Davis, CD 
1999 
Yes 
BioFactors
ISSN: 0951-6433
EISSN: 1872-8081 
10 
1 
15-24 
English 
10475586 
WOS:000085333800002 
Manganese is an essential trace element that is required for the activity of several enzymes. Manganese is also quite toxic when ingested in large amounts, such as the inhalation of Mn-laden dust by miners. This review examines Mn intake by way of the food supply and poses the question: Is there reason to be concerned with Mn toxicity or deficiency in free-living populations in North America? Although much remains to be learned of the functions of Mn, at present there are only a few vaguely desc about Mn toxicity under some very specialized conditions. Increasing numbers of young people are adopting a vegetarian lifestyle which may greatly increase Mn intake. Iron deficiency may increase Mn absorption and further increase the body-burden of Mn, especially in vegetarians. Mn is eliminated primarily through the bile, and hepatic dysfunction could depress Mn excretion and further contribute to the body burden. Would such a combination of events predispose substantial number