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HERO ID
2956720
Reference Type
Journal Article
Title
Robust and versatile pectin-based drug delivery systems
Author(s)
Marras-Marquez, T; Pena, J; Veiga-Ochoa, MD
Year
2015
Is Peer Reviewed?
Yes
Journal
International Journal of Pharmaceutics
ISSN:
0378-5173
EISSN:
1873-3476
Volume
479
Issue
2
Page Numbers
265-276
PMID
25542990
DOI
10.1016/j.ijpharm.2014.12.045
Web of Science Id
WOS:000350452600001
Abstract
Pectin-based resistant, interactive and versatile hydrogel vehicles for oral administration have been prepared. These systems are thought to be versatile enough to allow the inclusion of substances (such as the surfactants tested: Pluronic, Tween, Na Lauryl sulphate) that may contribute to tailor the drug release patterns. Tolbutamide, that shows a discrete and pH-dependent solubility in water, has been employed as a model drug to test the capability of these matrices to overcome such drug-imposed restraints. The incorporation of different surfactants produced pectin-based hydrogels of difficult manipulation. In order to improve this drawback, two different strategies have been developed: blending with agarose or freeze-drying. The presence of agarose yields robust systems that can be handled and tested as prepared, in the fresh state. Freeze-drying not only allows to shape pure pectin and blend systems, but also generates a porous structure whose microstructure, determined by the different components included, influences on the drug release behavior. Tolbutamide release kinetics from freshly prepared matrices can be fitted to the Higuchi model while the freeze-dried ones adjust to the Korsmeyer-Peppas model; hence the hydrogel chains rearrangement processes rule the release during the rehydration process. (C) 2014 Elsevier B.V. All rights reserved.
Keywords
Hydrogels; Pore architecture; Surfactants; Freeze-drying; Oral drug delivery; Kinetics
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