Risk of leukemia and multiple myeloma associated with exposure to benzene and other organic solvents: Evidence from the Italian multicenter case-control study | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2961506

Reference Type

Journal Article

Title

Risk of leukemia and multiple myeloma associated with exposure to benzene and other organic solvents: Evidence from the Italian multicenter case-control study

Author(s)

Seniori Costantini, A; Benvenuti, A; Vineis, P; Kriebel, D; Tumino, R; Ramazzotti, V; Rodella, S; Stagnaro, E; Crosignani, P; Amadori, D; Mirabelli, D; Sommani, L; Belletti, I; Troschel, L; Romeo, L; Miceli, G; Tozzi, GA; Mendico, I; Alberghini Maltoni, S; Miligi, L

Year

2008

Is Peer Reviewed?

Yes

Journal

American Journal of Industrial Medicine
ISSN: 0271-3586
EISSN: 1097-0274

Report Number

CIS/09/00555

Volume

Issue

Language

English

Abstract

This population-based case-control study was carried out to evaluate the association between exposure to organic solvents and risk of myeloid and lymphoid leukaemia and multiple myeloma (MM). Data concerning 586 cases of leukaemia and 1,278 population controls, as well as 263 cases of MM and 1,100 population controls were collected. Experts assessed exposure at individual level to a range of chemicals. No associations were found between exposures to any solvent and acute myeloid leukaemia. There were elevated point estimates for the associations between medium/high benzene exposure and chronic lymphatic leukaemia (odds ratio (OR) 1.8) and MM (OR 1.9). Other findings are discussed.