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2971349 
Journal Article 
The effect of cadmium on vitellogenin metabolism in estradiol-induced flounder (Platichthys flesus (L.)) males and females 
Povlsen, AF; Korsgaard, B; Bjerregaard, P 
1990 
Yes 
Aquatic Toxicology
ISSN: 0166-445X
EISSN: 1879-1514 
BIOSIS/91/31762 
AMST 
AMST 
253-262 
English 
BIOSIS COPYRIGHT: BIOL ABS. The effect of cadmium on metabolic processes related to vitellogenic reproduction was investigated in flounder males and females. One injection of 2 mg cadmium per kg body wt reduced the ratio of RNA to DNA in the liver to less than half of the control value and significantly depressed the concentration of the yolk-precursor protein vitellogenin in the plasma of estradiol-injected female flounders. A dose of 0.5 mg cadmium per kg body wt had no effect. In estradiol-induced flounder males cadmium treatment had a significant reducing effect on the level of circulating vitellogenin in the combined estradiol-cadmium treated group compared to the estradiol treated group. No effect of cadmium was observed on the ratio of hepatic RNA to DNA in the male fish. Of the investigated tissues the liver was the most important organ accumulating cadmium in male as well as in female flounders. By gel fractionation, it was found that 88% of the accumulated cadmium in the cadmium-estradiol