US EPA

2992177 

Journal Article 

Abstract 

Metabolism and disposition of ethalfluralin, a dinitroaniline herbicide, in male rats 

Hanasono, GK; Occolowitz, JL; Wolen, RL 

1978 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

45 

1 

321-321 

English 

WOS:A1978FL51900256 

The excretion, biotransformation, and enterohepatic circulation of ring-labeled [14C] ethalfuralin [N-ethyl- N- (2-methyl- 2-propenyl)- 2,6-dinitro- 4(trifluro methyl) benzeamine] was investigated in male rats given single oral doses (100 mg/kg). The 7-day urinary and fecal excretion of radiolabeled materials by intact animals accounted for 24 and 71%, respectively, of the administered radioactivity. Three urinary metabolites of ethalfluralin were identified by GC-MS and by high-resolution mass spectrometry. A major urinary metabolite (ca. 25% of urinary 14C) was identified as 2-(hydroxymethyl)- 3-[2,6-dinitro- 4-(trifluoro- methyl) phenylamine] propanoic acid. Animals with biliary fistulas excreted 32% of the radiocarbon dose into the bile by 24 hr and 41% by 48 hr. When bile containing 14C-labeled metabolites of ethal fluralin was infused into the duodenum of other bile duct-cannulated rats, 45% of the administered radioactivity reappeared in the 24-hr bile collection. This indicated that an appreciable portion of the labeled materials excreted into the bile undergoes enterohepatic circulation. [Presented at the 17th Annu. Mtg. of the Soc. of Toxicol.] (Author abstract by permission)