US EPA

2993334 

Journal Article 

Intravesical cidofovir to treat BK virus-associated hemorrhagic cystitis in children after hematopoietic stem cell transplantation 

Rascon, J; Verkauskas, G; Pasauliene, R; Zubka, V; Bilius, V; Rageliene, L 

2015 

1 

Pediatric Transplantation
ISSN: 1397-3142
EISSN: 1399-3046 

19 

4 

E111-E114 

English 

25882393 

10.1111/petr.12477 

WOS:000354182500008 

http://dx.doi.org/10.1111/petr.12477
Exit
 

HC related to BK virus replication might be a severe complication following allogeneic HSCT. There are no clearly defined treatment guidelines in pediatric population. The data on the effectiveness of ICI to manage severe bleeding in children are very limited. We report our experience of intravesical cidofovir in four children, 6-15 yr of age, to manage grade III-IV BK virus-associated HC. Three of four children had high CSA serum level prior to developing cystitis. Intravesical instillations of cidofovir resulted only in temporal relief of bleeding. After immune suppression was withdrawn or tapered, intravesical instillations of formalin solution had to be undertaken to abort severe bleeding. We concluded that intravesical cidofovir alone did not appear to be sufficiently effective in case of severe HC, necessitating complimentary procedures to stop macrohematuria. 

hematopoietic stem cell transplantation; hemorrhagic cystitis; BK virus; cidofovir; intravesical instillation