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2998659 
Journal Article 
The safety of calcium channel blockers in human pregnancy: a prospective, multicenter cohort study 
Magee, LA; Schick, B; Donnenfeld, AE; Sage, , SR; Conover, B; Cook, L; Mcelhatton, PR; Schmidt, MA; Koren, G 
1996 
Yes 
American Journal of Obstetrics & Gynecology
ISSN: 0002-9378
EISSN: 1097-6868 
174 
3 
823-828 
English 
8633650 
OBJECTIVE: Our purpose was to examine the potential teratogenicity of calcium channel blockers.

STUDY DESIGN: Six teratogen information services prospectively collected and followed up 78 women with first-trimester exposure to calcium channel blockers. Pregnancy outcome was compared (by paired t text of chi2 analysis) with that of a control group matched for maternal age and smoking.

RESULTS: There was no increase in major malformation (2/66=3.0% [calcium channel blockers] vs 0% [nonteratogenic controls], p=0.27); a fivefold increase was ruled out (baseline 2%, alpha = 0.05, beta = 0.20). The defects reported were attributable to maternal diabetes or coingestion of teratogens. The increase in preterm delivery 28% [calcium channel blockers] vs 9% [nonteratogenic controls], p=0.003), attributed to maternal disease by stepwise regression, was the most important factor responsible for the observed decrease in birth weight (mean -334 gm vs nonteratogenic controls, p=0.08).

CONCLUSION: This study suggests that calcium channel blockers do not represent a major teratogenic risk.