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95074 
Journal Article 
Persistence of vinyl chloride-induced liver injury after cessation of exposure 
Berk, PD; Martin, JF; Waggoner, JG 
1975 
Yes 
Annals of the New York Academy of Sciences
ISSN: 0077-8923
EISSN: 1749-6632 
NIOSH/00127924 
31246 
JAN31 
70-77 
English 
1054971 
WOS:A1975V673200007 
A case of vinyl-chloride (75014) (VC) induced liver injury was reported in a 30 year old white male. The patient had worked for 5.5 years in a job involving cleaning of tanks in which VC was polymerized. Two and half years following cessation of VC exposure, the patient was found to have hepatosplenomegaly which persisted over the 3 year period of study. Routine liver function tests, plasma disappearance studies, a diagnostic laparotomy, and a liver biopsy were performed. Histologic examination revealed features characteristic of VC associated hepatic fibrosis. Kinetic studies with radiobilirubin, bromsulphalein, and indocyanine-green generally yielded results within normal limits. Only the cholyl-glycine disappearance curve was abnormal. Results indicated that hepatic fibrosis persisted despite removal from further exposure. The authors note that the normal values observed for so many of the liver function tests in the presence of a significant histologic lesion in this patient indicates that there is a serious problem in designing an adequate regimen for the screening of VC exposed workers. 
Vinyl Compounds; Vinyl Chloride; WD06X94M2D; Index Medicus; Liver Function Tests; Kinetics; Liver -- pathology; Chemical and Drug Induced Liver Injury -- etiology; Occupational Diseases -- pathology; Vinyl Chloride -- blood; Vinyl Compounds -- poisoning; Vinyl Chloride -- poisoning; Chemical and Drug Induced Liver Injury -- pathology; Occupational Diseases -- etiology