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3003424 
Journal Article 
Hepatic angiosarcoma. Animal model: angiosarcoma of rats and mice induced by vinyl chloride 
Hong, CB; Winston, JM; Lee, CC 
1980 
1 
American Journal of Pathology
ISSN: 0002-9440
EISSN: 1525-2191 
101 
3 
737-740 
English 
7192493 
WOS:A1980KV41200016 
Vinyl chloride (VC, CH2=CHCL) is a monomer used mainly to make polyvinyl chloride (PVC), an essential material to our daily life. In 1974, Creech and Johnson reported hepatic angiosarcoma in workers associated with the manufacture pf PVC. The first case of hepatic angiosarcoma in VC workers was identified in 1961. This finding was later substantiated by experimental inhalation study in laboratory animals. Microscopic features and tumorigenesis of hepatic angiosarcoma from rats and mice induced by VC resembles closely that which develops in man exposed to VC, thorotrast, and arsenic. Vinyl chloride is able to induce hepatic angiosarcoma in many species of laboratory animals. The model can be used to set up guidelines for the tolerance level of VC for workers in PVC plants. The model also provides an opportunity to study the possible adverse effects on the hepatocytes, including tumor induction, caused by the dysfunction of the other components of liver. Similar to other experimental tumors, this model will add another reproducible system to the study of the tumorigenesis, treatment, and prevention of neoplasms in man.