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3006593 
Journal Article 
Dissolution system for nifedipine sustained release formulations 
Chaudhary, RS; Gangwal, SS; Gupta, VK; Shah, YN; Khanna, S; Et al 
1994 
Yes 
Drug Development and Industrial Pharmacy
ISSN: 0363-9045
EISSN: 1520-5762 
IPA/95/1065132 
Ind 
REF 11 
1267-1274 
English 
IPA COPYRIGHT: ASHP To assess the dissolution of sustained-action nifedipine and to evaluate an in vitro dissolution method, a modified USP dissolution apparatus type 2 using simulated gastric fluid and octyl alcohol (1-octanol) was compared to the standard USP dissolution apparatus 2, both with additional paddles, using 2 commercially available nifedipine preparations. Results indicated that the modified apparatus delivered consistent, reproducible results and was found to be good for in vitro dissolution rate evaluation of sustained-release nifedipine tablets.