Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
3015025
Reference Type
Journal Article
Title
Nebulizers for drug delivery to the lungs
Author(s)
Martin, AR; Finlay, WH
Year
2015
Is Peer Reviewed?
Yes
Journal
Expert Opinion on Drug Delivery
ISSN:
1742-5247
EISSN:
1744-7593
Volume
12
Issue
6
Page Numbers
889-900
Language
English
PMID
25534396
DOI
10.1517/17425247.2015.995087
Web of Science Id
WOS:000354800400004
Abstract
INTRODUCTION:
Nebulizers are the oldest modern method of delivering aerosols to the lungs for the purpose of respiratory drug delivery. While use of nebulizers remains widespread in the hospital and home setting, certain newer nebulization technologies have enabled more portable use. Varied fundamental processes of droplet formation and breakup are used in modern nebulizers, and these processes impact device performance and suitability for nebulization of various formulations.
AREAS COVERED:
This review first describes basic aspects of nebulization technologies, including jet nebulizers, various high-frequency vibration techniques, and the use of colliding liquid jets. Nebulizer use in hospital and home settings is discussed next. Complications in aerosol droplet size measurement owing to the changes in nebulized droplet diameters due to evaporation or condensation are discussed, as is nebulization during mechanical ventilation.
EXPERT OPINION:
While the limelight may often appear to be focused on other delivery devices, such as pressurized metered dose and dry powder inhalers, the ease of formulating many drugs in water and delivering them as aqueous aerosols ensures that nebulizers will remain as a viable and relevant method of respiratory drug delivery. This is particularly true given recent improvements in nebulizer droplet production technology.
Keywords
droplet formation; droplet sizing; inhalation drug delivery; jet nebulizers; nebulizers; respiratory drug delivery; vibrating membrane; vibrating mesh
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity