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HERO ID
3023449
Reference Type
Journal Article
Title
The Transport and Deposition of Nanoparticles in Respiratory System by Inhalation
Author(s)
Qiao, H; Liu, W; Gu, H; Wang, D; Wang, Yu
Year
2015
Is Peer Reviewed?
Yes
Journal
Journal of Nanomaterials
ISSN:
1687-4110
EISSN:
1687-4129
DOI
10.1155/2015/394507
Web of Science Id
WOS:000355431300001
Abstract
The inhaled nanoparticles have attracted more and more attention, since they are more easily to enter the deep part of respiratory system. Some nanoparticles were reported to cause pulmonary inflammation. The toxicity of nanoparticles depends not only on its chemical component but also on the quantity and position of the deposition. The deposition of nanoparticles is not uniform and is influenced by airflow transport. The high deposition mainly occurs at the carinal ridges and the inside walls around the carinal ridges. Many factors could affect the transport and deposition of nanoparticles, such as particle size, flow rate, structure of airway, pulmonary function, and age. In this review, we discussed the methods and technique involved in particle transport and deposition studies. The features of particles deposition could be observed in clinic experiments and animal experiments. The mechanism of transport could be studied by numerical simulation. Numerical model and experiment study supplement each other. Some techniques such as medical imaging may support the study of nanoparticles transport and deposition. The knowledge of particles transport and deposition may be helpful both to defend the toxicity of inhaled particles and to direct inhaled drug delivery.
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