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3023697 
Journal Article 
Sustained-Release Tablets of Pridinol Mesylate: Preparation and Examination of In Vitro Release Rate 
Luo, Lei; Luo, Min; Luo, Y; Bourkaib, N 
2014 
0 
Latin American Journal of Pharmacy
ISSN: 0326-2383 
33 
7 
1175-1181 
WOS:000344932500016 
The aim of the present study is to prepare the sustained-release tablets of pridinol mesylate (PM) and to determine the in vitro release rates. The formula was optimized according to the tablets releasing with one factor at a time experiment and orthogonal test. Rotating basket method coupling with HPLC analysis was used to determine the dissolution rate of sustained-release tablets of PM in vitro. The optimized prescription for a tablet (tablet weight 200 mg) was composed of PM 12 mg, HPMC 4M 60 mg, EC 40 mg, starch 82 mg, CMC-Na 4 mg, and magnesium stearate 2 mg. In vitro drug release results of PM sustained-release tablets were over 12 h. The conclusion of this research is the formula optimized PM sustained-release tablets has excellent in vitro slow release property and they are expected to reduce the frequency of administration and therefore improve the medication compliance of patient. Drug diffusion could fit first order kinetics equation; drug diffusing and matrix erosion were happened simultaneously during the releasing process. 
In vitro; Pridinol mesylate; Release rate; Sustained-release tablets