Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
3040155
Reference Type
Journal Article
Title
Effects of the Renin-Angiotensin Blockade on Renal Functions, Renal Norepinephrine Contents and Oxidative Stress in Cyclosporine Induced Nephrosis Rats
Author(s)
Panasjaroen, S; Kalandakanond-Thongsong, S; Buranakarl, C
Year
2008
Is Peer Reviewed?
1
Journal
The Thai Journal of Veterinary Medicine / Wetchasan Sattawaphaet
ISSN:
0125-6491
Volume
38
Issue
3
Page Numbers
9-18
Web of Science Id
WOS:000260885000002
Abstract
The experiment was conducted to investigate the effects of renin-angiotensin blockade on renal function, renal norepinephrine (NE) contents and renal oxidative stress in Cyclosporine A (CsA) induced renal impairment in rats. Rats were assigned into three groups; group I (control group), receiving vehicle (propylene glycol) 1 ml/kg./day, subcutaneously (s/c). for 28 days; group 2 (CsA group), receiving CsA 15 mg/kg/day, s/c for 28 days; group 3 (CsA and losartan (LST) group), receiving CsA 15 mg/kg./day, s/c with the administration of LST 10 mg/k.g./day orally for 28 days. The results showed that CsA administration alone elevated mean arterial pressure (MAP), reduced renal function, as assessed by increased plasma urea nitrogen and decreased glomerular filtration rate. CsA stimulated renal sympathetic activity as assessed by increased renal NE content and induced oxidative stress, as indicated by increased renal malondialdehyde (MDA) and decreased concentrations of renal reduced glutathione (GSH). Losartan, the angiotensin type 1 (AT,) receptor antagonist markedly decreased MAP, improved renal function, reduced renal NE content and reduced renal MDA. It is concluded that enhanced renal sympathetic activity and oxidative stress by CsA were mediated by angiotensin II. Blocking the renin-angiotensin system can ameliorate the renal impairment caused by CsA.
Keywords
cyclosporine; losartan; norepinephrine; oxidative stress; rats
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity