US EPA

3040774 

Technical Report 

Solubility and dielectric constant correlations of the systems chloramphenicol palmitate-propylene glycol-water 

Rogers, JA; Nairn, JG 

1973 

IPA/74/114117 

J 

REF 21 

75-77 

IPA COPYRIGHT: ASHP The solubility of chloramphenicol palmitate in propylene glycol-water systems was determined. The solubility was found to be 0.004 mg./ml. in pure water and 4.95 mg./ml. in pure propylene glycol. Additions of propylene glycol to water do not significantly alter the water solubility of the antibiotic ester until about 60% w/w has been added, then the solubility increases logarithmically in a manner approximately proportional to the propylene glycol concentration of the system. Using available data on the dielectric constants of these solvents, a solubility parameter for chloramphenicol palmitate has been calculated to be 11.8. Correlations between solubility and dielectric constant do not show a dielectric requirement, instead a critical dielectric constant or propylene glycol concentration required to increase the solubility of the drug is considered to be more applicable.