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3040870 
Journal Article 
Propylene glycol intoxication and lactic acidosis 
Cate, JC; Hedrick, R 
1980 
1 
New England Journal of Medicine
ISSN: 0028-4793
EISSN: 1533-4406 
IPA/80/420025 
Engl 
REF 9 
English 
IPA COPYRIGHT: ASHP Reported is a case of propylene glycol (I) intoxication in a 58-yr-old schizophrenic man with renal disease, accompanied by the development of lactic acidosis and I levels of 70 mg/dl in the blood and 60 mg/dl in the urine. The patient quickly responded to IV fluids and sodium bicarbonate. Lactic acidosis may have developed as a result of a large excess of I that was metabolized to lactic acid. Since the patient had azotemic renal disease, I probably accumulated in the blood because of impaired renal clearance secondary to renal disease.