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3040968 
Journal Article 
Effect of polyols on interaction of paraben preservatives with polysorbate 80 
Blanchard, J 
1980 
Yes 
Journal of Pharmaceutical Sciences
ISSN: 0022-3549
EISSN: 1520-6017 
IPA/82/478021 
Pharm 
REF 38 
169-173 
English 
IPA COPYRIGHT: ASHP A quantitative study of the interaction of butyl, ethyl, methyl and propyl parabens with polysorbate 80, with or without 2 polyols (propylene glycol and glycerol (glycerin)), which were potential competitors, was performed. The results indicated that neither competitor displaced significant amounts of the parabens from their binding sites on polysorbate 80.