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3041108 
Technical Report 
Effect of plasticizer type and concentration on the incidence of bridging of intagliations on film coated tablets 
Rowe, RC; Forse, SF 
1981 
IPA/81/453063 
Pharm 
REF 5 
174-175 
English 
IPA COPYRIGHT: ASHP The incidence of the bridging of intagliations was evaluated in tablets coated with a film formulation consisting of a 5% w/v aqueous solution of hydroxypropyl methylcellulose (Pharmacoat 606) to which was added either glycerol (glycerin; I), propylene glycol (II) or polyethylene glycol 200 (III) at varying concentrations (10, 20 and 30% w/w based on the polymer used). Results showed that at the 10 and 20% w/w level, the rank order of plasticizer efficiency as measured by the lowering of the incidence of the defect is III, II and I. At the 30% level, the results for III and II are not significantly different.