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HERO ID
3041108
Reference Type
Technical Report
Title
Effect of plasticizer type and concentration on the incidence of bridging of intagliations on film coated tablets
Author(s)
Rowe, RC; Forse, SF
Year
1981
Report Number
IPA/81/453063
Volume
Pharm
Issue
REF 5
Page Numbers
174-175
Language
English
Abstract
IPA COPYRIGHT: ASHP The incidence of the bridging of intagliations was evaluated in tablets coated with a film formulation consisting of a 5% w/v aqueous solution of hydroxypropyl methylcellulose (Pharmacoat 606) to which was added either glycerol (glycerin; I), propylene glycol (II) or polyethylene glycol 200 (III) at varying concentrations (10, 20 and 30% w/w based on the polymer used). Results showed that at the 10 and 20% w/w level, the rank order of plasticizer efficiency as measured by the lowering of the incidence of the defect is III, II and I. At the 30% level, the results for III and II are not significantly different.
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