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3041112 
Journal Article 
Physical chemical properties of alpha styryl carbinol antifungal agents 
Maurin, MB; Addicks, WJ; Rowe, SM; Hogan, R 
1993 
1 
Pharmaceutical Research
ISSN: 0724-8741
EISSN: 1573-904X 
IPA/93/1034203 
Res 
REF 8 
309-312 
English 
IPA COPYRIGHT: ASHP The thermal properties, solubility, ionization behavior, and solid-state and solution stability of some alpha styryl carbinol antifungal agents were examined. The compounds were characterized by poor aqueous solubility, ranging from 3 to 20 mcg/ml as a function of pH. The ionization of the compounds was dependent on a triazole ring that was a very weak base, with a pKa ranging from 1.7 to 2.2. Their solubility was enhanced with the cosolvents propylene glycol, polyethylene glycol 400, and glycerin. However, in the cosolvent systems, oxidative degradation to the corresponding epoxide was observed.