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3041807 
Journal Article 
Testing antiacne agents in Mexican hairless dogs 
Loux, JJ; Depalma, RD; Yankell, SL 
1974 
0 
Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832 
IPA/76/188097 
Soc 
REF 17 
473-479 
English 
IPA COPYRIGHT: ASHP The suitability of Mexican hairless dogs in the evaluation of acne preparations was studied. Materials tested included sulfur, hexachlorophene, salicylic acid, benzoyl peroxide, and vitamin A acid (tretinoin). The use of a bland soap (Ivory) or an abrasive soap (Amo-Derm) on site cleaning and comedone removal was also evaluated. Soap treatments cleaned follicle-containing areas but did not remove follicular plugs. Salicylic acid preparations (1-3%) were similarly ineffective. The use of 10% benzoyl peroxide produced slight extrusion of the follicular keratin plus mild irritation; retinoic acid 0.1% in an ethyl alcohol-propylene glycol vehicle caused marked comedone extrusion and irritation.