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3041839 
Journal Article 
The effect of spironolactone pretreatment on the biliary excretion and renal accumulation of inorganic mercury in the rat 
Kitani, K; Miura, R; Kanai, S; Morita, Y 
1977 
Yes 
Biochemical Pharmacology
ISSN: 0006-2952
EISSN: 1873-2968 
HEEP/78/11068 
26 
19 
1823-1824 
WOS:A1977DS16200016 
HEEP COPYRIGHT: BIOL ABS. A water suspension of powdered Aldactone was given orally through a stomach tube, or injected i.p. Ethylene glycol suspension was given i.p. The Sp (spironolactone) dose was 5 mg/100 body weight. In control rats, only ethylene glycol or propylene glycol was administered i.p. Hg excretion studies were performed on rats 1-2 h after the pretreatment. The recovery of the i.v. administered Hg in the bile and the Hg content in these organs were measured for their radioactivity. Differences in the effect of Sp on the biliary excretion of Hg appear to be due to the difference in the Hg dose used and not to the difference in the administration or the material used as was suspected previously. An i.p. injection appears to be more effective in decreasing the Hg content in the kidneys in comparison with oral administration (P and lt; 0.01). Furthermore, an i.p. injection of pure Sp was more effective than Aldactone injection (P and lt; 0.025) in decreasing the kidney content of Hg. The significant difference in the Hg content of the kidney between orally administered and i.p. injected rats and between rats given Aldactone and pure Sp suggests that the difference in the administration and the material used might cause a difference in the degree of protection against Hg poisoning despite similar biliary excretion of Hg.