US EPA

3041935 

Journal Article 

Evaluation of the Developmental Toxicity of Inhaled Dipropylene Glycol Monomethyl Ether (DPGME) in Rabbits and Rats 

Breslin, WJ; Cieszlak, FS; Zablotny, CL; Corley, RA; Verschuuren, HG; Yano, BL 

1996 

0 

Occupational Hygiene
ISSN: 1061-0251 

2 

1-6 

English 

WOS:A1996BF72T00016 

The maternal and developmental toxicities of dipropylene-glycol-monomethyl-ether (20324327) (DPGME) were evaluated in rabbits and rats. The DPGME used was a commercial mixture of four isomers with a maximum theoretical yield of 61.8% of the beta isomer of propylene-glycol-methyl-ether (107982) (beta-PGME). New-Zealand-White-rabbits and Fischer-344-rats were used in the study. Groups of 16 inseminated rabbits or 32 to 37 bred rats were exposed via inhalation for 6 hours a day to 0, 50, 150, or 300 parts per million (ppm) DPGME on gestation days seven through 19 for rabbits and six through 15 for rats. No treatment related effects on the reproductive and fetal parameters recorded, or on the incidence of malformations or variations in fetuses were observed at any exposure level in either species. The exposure levels were not maternally toxic, embryo/fetotoxic or teratogenic. The authors conclude that since no developmental effects were observed in either rabbits or rats following exposure to 300ppm DPGME, the highest concentration of DPGME practicably attainable at room temperature and pressure, it is unlikely that sufficient atmospheric concentrations of DPGME could be generated to result in the formation of sufficient amounts of metabolite beta-PGME to represent a developmental hazard following DPGME exposure. 

developmental toxicity; dipropylene glycol monomethyl ether; rabbit; rat