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3042058 
Journal Article 
Transdermal transport of piroxicam from ointment bases 
Pandey, RK; Ganga, S; Jayaswal, SB; Singh, J 
1992 
Yes 
Die Pharmazie
ISSN: 0031-7144 
IPA/93/1025289 
VOL 47 ISS Oct 1992 
REF 16 
800-801 
English 
IPA COPYRIGHT: ASHP To investigate the effect of vehicle and non-ionic surfactant on the transport of piroxicam, 11 hydrophilic ointments were prepared and evaluated for permeation through full thickness rat skin. Results indicated that an increase in the concentration of propylene glycol from 10 to 20% increases permeation of the drug. An increase of polysorbate 20 from 10 to 20% also increases the permeation of the drug. It was concluded that polysorbate 20 and polyethylene glycol, in combination, markedly enhance the in vitro transport of piroxicam through rat skin.