Health & Environmental Research Online (HERO)


Print Feedback Export to File
3044056 
Journal Article 
Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(eta(6)-p-cymene)Cl-2(pta) 
Scolaro, C; Hartinger, CG; Allardyce, CS; Keppler, BK; Dyson, PJ 
2008 
Yes 
Journal of Inorganic Biochemistry
ISSN: 0162-0134
EISSN: 1873-3344 
102 
9 
1743-1748 
English 
18582946 
WOS:000258637600007 
The hydrolysis of [Ru(eta(6)-p-cymene)Cl-2(PTA)] (PTA = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine; RAPTA-C) was studied using UV-visible (UV-vis) spectrophotometry and NMR spectroscopy. in analogy to in silico, studies, [Ru(eta(6)-p-cymene)Cl(H2O)(PTA)](+) was found to be the most abundant hydrolysis product, although the dihydrolysed species [Ru(eta(6)-p-cymene)(OH)(H2O)(PTA)](+) and the dichloro compound are present. Rate constants for the different aquation and anation steps and the equilibrium constants were determined. Hydrolysis is suppressed at high chloride concentrations. These results have important implications on the mode of action of the RAPTA drug candidates. (C) 2008 Elsevier Inc. All rights reserved. 
anticancer research; hydrolysis; RAPTA-C; ruthenium complex; UV-vis spectrophotometry; NMR spectroscopy